منابع مشابه
Phytohemagglutinin Mitogenic Proteins
The phytohemagglutinin (PHAP) glycoproteins derived from Phaseolus vulgaris consist of five isomitogens that are tetrameric structures made up of two different glycoprotein subunits. Although identical in size (mol wt = 34,000), the subunits differ in their isoelectric points and amino acid sequences for six of the first seven amino-terminal residues, but are identical in primary structure from...
متن کاملExtensive homology between the subunits of the phytohemagglutinin mitogenic proteins derived from Phaseolus vulgaris.
The phytohemagglutinin mitogenic proteins derived from Phaseolus vulgaris comprise a class of five glycoproteins that are isomeric tetramers composed of varying proportions of two different subunits (L and R). Within the native tetramer, the L subunit is a potent leukoagglutinin and mitogen that lacks hemagglutinating properties, whereas the R subunit is a potent hemagglutinin with little or no...
متن کاملAn assay for the mitogenic activity of phytohemagglutinin preparations.
By Douci &ss C. TORMEY AND GERALD C. MUELLER T HE ADDITION of phytohemagglutinin, an extract of the kidney bean Phaseolus vulgaris, to cultures of human peripheral lymphocytes promotes the synthesis of v-globulin, ribonucleic acid (RNA), and desoxyribonucleic acid (DNA), and induces mitosis in a large fraction of lymphocytes.1’7 The present communication describes an assay in which the graded i...
متن کاملMitogenic effects of purified outer membrane proteins from Pseudomonas aeruginosa.
Three major outer membrane proteins from Pseudomonas aeruginosa PAO1 were purified and tested for their ability to stimulate resting murine lymphocytes to proliferate. It was demonstrated that picomole amounts of all three proteins were mitogenic for both intact and T-lymphocyte-depleted populations of spleen cells from C3H/HeJ mice. In contrast, they had no activity against either mature or im...
متن کاملESCRT proteins, endosome organization and mitogenic receptor down-regulation.
Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface. After reaching the early endosome, they are ubiquitinated within their cytosolic domain and are consequently sorted away from recycling receptors. They are then incorporated into intraluminal vesicles within the MVB (multivesicular body) en route t...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1973
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.138.4.939